Anti-epileptic effect of morin against experimental pentylenetetrazol-induced seizures via modulating brain monoamines and oxidative stress

Objective: To evaluate the protective effect of morin against pentylenetetrazol (PTZ)-induced tonic-clonic convulsions in mice. Methods: Swiss albino mice (18-22 g) was used to induce convulsions by intraperitoneal (i.p.) administration of PTZ (90 mg/kg). Mice were either pretreated with morin (10, 20 and 40 mg/kg) or vehicle (distilled water, 10 mg/kg) 45 min before PTZ administration. Various behavioral and biochemical parameters were assessed. Results: PTZ administration resulted in significant production (P<0.001) of tonic-clonic conclusion and mortality in mice. PTZ-induced increase in the duration of convulsion, onset of convulsion and mortality was inhibited significantly by morin (20 and 40 mg/kg) administration. The PTZ-induced decrease in brain GABA, dopamine and Na

Cognitive management of cerebral palsy with unani formulation [a clinical trial]

Modem medicine is trying to introduce a number of experimental therapies for reversal of neuronal damage or enhancement of neuronal functions. One of this is Unani therapy for cognitive management. We prepared an in-house formulation called Majoon Intelligent Quotient [MIQ]. The ingredients were selected based upon an extensive literature survey about their usage in neurological conditions. Small Cerebral Palsy children aged 2-6 years were selected from UDAAN, one of India's premier center for management of small moderate to severe CP children. The overall opinion on the drug seems to show a 50% responder rate in cognitive parameters in small CP children with moderate to severe cerebral palsy. We feel that this drug will have an important role in early Interventional therapy of small CP children specially those with cognitive impairment